Journal
NATURE REVIEWS IMMUNOLOGY
Volume 10, Issue 6, Pages 427-439Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2779
Keywords
-
Categories
Funding
- Deutsche Forschungsgemeinschaft [SO876/3-1, SO876/4-1, FOR809]
- German Heart Foundation
- German Foundation of Heart Research
- Faculty of Medicine at the RWTH Aachen University
- Swedish Research Council
- Swedish Heart-Lung Foundation
- Swedish Foundation for Strategic Research
- Karolinska Institutet
Ask authors/readers for more resources
Neutrophils, monocytes and macrophages are closely related phagocytic cells that cooperate during the onset, progression and resolution of inflammation. This Review highlights the mechanisms involved in the intimate partnership of phagocytes during each progressive phase of the inflammatory response. We describe how tissue-resident macrophages recognize tissue damage to promote the recruitment of neutrophils and the mechanisms by which infiltrating neutrophils can then promote monocyte recruitment. Furthermore, we discuss the phagocyte-derived signals that abrogate neutrophil recruitment and how the uptake of apoptotic neutrophils by macrophages leads to termination of the inflammatory response. Finally, we highlight the potential therapeutic relevance of these interactions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available