Journal
NATURE REVIEWS IMMUNOLOGY
Volume 10, Issue 1, Pages 24-35Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2685
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Funding
- US National Institutes of Health
- American College of Rheumatology
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Transcriptional control mechanisms chart the course of the inflammatory response by synthesizing mRNAs encoding proteins that promote or inhibit inflammation. Because these mRNAs can be long-lived, turning off their synthesis does not rapidly stop or change the direction of inflammation. Post-transcriptional mechanisms that modify mRNA stability and/or translation provide more rapid and flexible control of this process and are particularly important in coordinating the initiation and resolution of inflammation. Here, I review the surprising variety of post-transcriptional control mechanisms that regulate the initiation and resolution of inflammation and discuss how these mechanisms are integrated to coordinate this essential process.
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