Journal
REVISTA ESPANOLA DE ANESTESIOLOGIA Y REANIMACION
Volume 57, Issue 3, Pages 181-184Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0034-9356(10)70194-8
Keywords
Myasthenia gravis; Sugammadex; Rocuronium; Neuromuscular blockade; Reversal drug
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A neuromuscular blocking drug (NMBD) induced neuromuscular blockade (NMB) in patients with myasthenia gravis usually dissipates either spontaneously or by administration of neostigmine. We administered sugammadex to a patient with myasthenia gravis to reverse a rocuronium-induced profound NMB. NMBDs predispose such patients to severe postoperative residual paralysis and respiratory complications. Sugammadex binds steroidal NMBDs and, therefore reverses a rocuronium or vecuronium-induced NMB, without interfering with cholinergic transmission. A rapid and complete recovery from profound NMB was achieved and no adverse events were observed. This case suggests that sugammadex is a safe and effective antagonist of a rocuronium induced NMB blockade in patients with myasthenia gravis.
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