Journal
NATURE REVIEWS IMMUNOLOGY
Volume 10, Issue 1, Pages 47-58Publisher
NATURE PORTFOLIO
DOI: 10.1038/nri2689
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Funding
- US National Institutes of Health [R01 AI64332, PO1 AI44220]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI064332, P01AI044220] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK040561] Funding Source: NIH RePORTER
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The genetically tractable model organism Caenorhabditis elegans was first used to model bacterial virulence in vivo a decade ago. Since then, great strides have been made in identifying the host response pathways that are involved in its defence against infection. Strikingly, C. elegans seems to detect, and respond to, infection without the involvement of its homologue of Toll-like receptors, in contrast to the well-established role for these proteins in innate immunity in mammals. What, therefore, do we know about host defence mechanisms in C. elegans and what can they tell us about innate immunity in higher organisms?
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