Journal
BRITISH JOURNAL OF DERMATOLOGY
Volume 161, Issue -, Pages 90-95Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1365-2133.2009.09455.x
Keywords
apoptosis; carcinogenesis; DNA repair; human papilloma virus; immune surveillance; immuno suppression; ultraviolet radiation
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P>Ultraviolet (UV) radiation is a complete carcinogen. The effects of UV radiation are mediated via direct damage to cellular DNA in the skin and suppression of image surveillance mechanisms. In the context of organ transplantation, addiction of drugs which suppress the immune system add greatly to the carcinogenicity of UV radiation. This review considers the mechanisms of such effects.
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