Journal
BRITISH JOURNAL OF DERMATOLOGY
Volume 160, Issue 1, Pages 183-185Publisher
WILEY
DOI: 10.1111/j.1365-2133.2008.08905.x
Keywords
atopic dermatitis; eosinophils; IgE; Staphylococcus aureus
Categories
Funding
- [N01 A140029]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [N01AI040029] Funding Source: NIH RePORTER
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Staphylococcal colonization of the skin is commonly observed in subjects with atopic dermatitis (AD) and correlates with disease severity. Little is known about whether the degree of T-helper 2 (Th2) polarity in these subjects can also affect the frequency of bacterial colonization in this disease. To determine if there is a correlation between markers of Th2 polarity [serum total IgE, eosinophilia and presence of another atopic disease (allergic rhinitis)] and skin colonization with Staphylococcus aureus in subjects with AD. A retrospective chart review was performed of an academic dermatology clinic focused on the treatment of AD with a single provider. Staphylococcus aureus colonization was more commonly observed in subjects with AD who had peripheral eosinophilia, elevated serum IgE levels, and/or a history of or active allergic rhinitis. Results suggest that Th2 polarity may enhance subjects' risk for bacterial colonization.
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