Journal
BRITISH JOURNAL OF DERMATOLOGY
Volume 161, Issue 2, Pages 373-383Publisher
WILEY
DOI: 10.1111/j.1365-2133.2009.09049.x
Keywords
atopic dermatitis; breastfeeding; cohort studies; meta-analysis
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Background Breastfeeding is undisputedly preferable to formula feeding for infant nutrition because of its nutritional, immunological and psychological benefits. However, studies on the association between breastfeeding and development of atopic dermatitis (AD) have shown inconsistent results. Objectives To examine the association between exclusive breastfeeding for at least 3 months after birth and the development of AD in childhood. Methods An electronic literature search of MEDLINE (January 1966-May 2008) and EMBASE (1980-May 2008) was conducted. Prospective cohort studies that met the predetermined criteria were independently assessed by three reviewers. The pooled effect estimate was calculated by random effects model. Heterogeneity across the studies was investigated by meta-regression analysis. Results Twenty-one studies with 27 study populations were included for meta-analysis. The summary odds ratio (OR) for the effect of exclusive breastfeeding on the risk of AD was 0 center dot 89 (95% confidence interval, CI 0 center dot 76-1 center dot 04). Heterogeneity was found across the studies (KH2 = 83 center dot 6, d.f. = 26; P < 0 center dot 001). Breastfeeding was associated with a decreased risk of AD (OR 0 center dot 70; 95% CI 0 center dot 50-0 center dot 99) when analysis was restricted to the studies comparing breastfeeding with conventional formula feeding. The pooled OR for study populations with atopic heredity was 0 center dot 78 (95% CI 0 center dot 58-1 center dot 05). Conclusions There is no strong evidence of a protective effect of exclusive breastfeeding for at least 3 months against AD, even among children with a positive family history.
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