Journal
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Volume 68, Issue 4, Pages 484-492Publisher
WILEY
DOI: 10.1111/j.1365-2125.2009.03486.x
Keywords
endothelial progenitor cell; endothelium; mobilization; vascular repair
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Funding
- Guy's
- St Thomas' Charity
- Department of Health via the National Institute for Health Research (NIHR)
- Guy's & St Thomas' NHS Foundation Trust
- King's College Hospital NHS Foundation Trust
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Endothelial progenitor cells are a population of bone marrow-derived mononuclear cells thought to engage in endothelial repair and hence are considered potential therapeutic agents in many pathological conditions. The mechanism of their exit from the bone marrow to the circulation and damaged tissues, termed mobilization, has not been fully elucidated. Despite this, several pharmacological interventions have been shown to influence mobilization of these specialized cells. Here we review the current understanding of their mobilization.
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