Journal
ACS CHEMICAL BIOLOGY
Volume 10, Issue 7, Pages 1604-1609Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acschembio.5b00245
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Funding
- National Cancer Institute [4R00CA166517-03]
- US National Institute of Health [5R01CA097061, 5R01GM085081, R01CA161061]
- NYSTEM
- Austrian Academy of Sciences
- Swiss NSF
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Little is known about the regulation of nonapoptotic cell death. Using massive insertional mutagenesis of haploid KBM7 cells we identified nine genes involved in small-molecule-induced nonapoptotic cell death, including mediators of fatty acid metabolism (ACSL4) and lipid remodeling (LPCAT3) in ferroptosis. One novel compound, CIL56, triggered cell death dependent upon the rate-limiting de novo lipid synthetic enzyme ACC1. These results provide insight into the genetic regulation of cell death and highlight the central role of lipid metabolism in nonapoptotic cell death.
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