Journal
BRITISH JOURNAL OF CANCER
Volume 110, Issue 9, Pages 2165-2169Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2014.190
Keywords
advanced biliary tract cancer; chemotherapy; prognostic factors; second-line
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Background: The role of second-line chemotherapy (CT) is not established in advanced biliary tract cancer (aBTC). We investigated the outcome of aBTC patients treated with second-line CT and devised a prognostic model. Methods: Baseline clinical and laboratory data of 300 consecutive aBTC patients were collected and association with overall survival (OS) was investigated by multivariable Cox models. Results: The following parameters resulted independently associated with longer OS: Eastern Cooperative Oncology Group performance status of 0 (P<0.001; hazard ratio (HR), 0.348; 95% confidence interval (CI) 0.215-0.562), CA19.9 lower than median (P = 0.013; HR, 0.574; 95% CI 0.370-0.891), progression-free survival after first-line CT >= 6 months (P = 0.027; HR, 0.633; 95% CI 0.422-0.949) and previous surgery on primary tumour (P 0.027; HR, 0.609; 95% CI 0.392-0.945). We grouped the 249 patients with complete data available into three categories according to the number of fulfilled risk factors: median OS times for good-risk (zero to one factors), intermediate-risk (two factors) and poor-risk (three to four factors) groups were 13.1, 6.6 and 3.7 months, respectively (P<0.001). Conclusions: Easily available clinical and laboratory factors predict prognosis of aBTC patients undergoing second-line CT. This model allows individual patient-risk stratification and may help in treatment decision and trial design.
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