Journal
BRITISH JOURNAL OF CANCER
Volume 110, Issue 6, Pages 1545-1551Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2014.33
Keywords
lung carcinoma; prognosis; survival; TGFBI; adjuvant therapy
Categories
Funding
- 'UTE project CIMA'
- European Union [QLG1-CT-2002-01735, HEALTH-F2-2010-258677]
- Spanish Government, European Regional Development Fund (ERDF) 'Una manera de hacer Europa' [ISCIII-RTICCRD12/0036/0040]
- Spanish Ministry of Science and Innovation (FIS) [PI10/00166, PI10/02131]
Ask authors/readers for more resources
Background: Transforming growth factor beta-induced protein (TGFBI) is a secreted protein that mediates cell anchoring to the extracellular matrix. This protein is downregulated in lung cancer, and when overexpressed, contributes to apoptotic cell death. Using a small series of stage IV non-small cell lung cancer (NSCLC) patients, we previously suggested the usefulness of TGFBI as a prognostic and predictive factor in chemotherapy-treated late-stage NSCLC. In order to validate and extend these results, we broaden the analysis and studied TGFBI expression in a large series of samples obtained from stage I-IV NSCLC patients. Methods: TGFBI expression was assessed by immunohistochemistry in 364 completely resected primary NSCLC samples: 242 adenocarcinomas (ADCs) and 122 squamous cell carcinomas (SCCs). Kaplan-Meier curves, log-rank tests and the Cox proportional hazards model were used to analyse the association between TGFBI expression and survival. Results: High TGFBI levels were associated with longer overall survival (OS, P < 0.001) and progression-free survival (PFS, P < 0.001) in SCC patients who received adjuvant platinium-based chemotherapy. Moreover, multivariate analysis demonstrated that high TGFBI expression is an independent predictor of better survival in patients (OS: P = 0.030 and PFS: P = 0.026). Conclusions: TGFBI may be useful for the identification of a subset of NSCLC who may benefit from adjuvant therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available