Journal
BRITISH JOURNAL OF CANCER
Volume 110, Issue 5, Pages 1328-1333Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2014.17
Keywords
folate; one-carbon metabolism pathway; esophageal cancer; gastric cancer
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Funding
- NIH, National Cancer Institute, Department of Health and Human Services
- Florida Department of Health, Tallahassee, Florida, USA
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Background: Nutrients in the one-carbon metabolism pathway may be involved in carcinogenesis. Few cohort studies have investigated the intakes of folate and related nutrients in relation to gastric and esophageal cancer. Methods: We prospectively examined the association between self-reported intakes of folate, methionine, vitamin B6, and vitamin B12 and gastric and esophageal cancer in 492 293 men and women. Results: We observed an elevated risk of esophageal squamous cell carcinoma with low intake of folate (relative risk (95% confidence interval): Q1 vs Q3, 1.91 (1.17, 3.10)), but no association with high intake. Folate intake was not associated with esophageal adenocarcinoma, gastric cardia adenocarcinoma, or non-cardia gastric adenocarcinoma. The intakes of methionine, vitamin B6, and vitamin B12 were not associated with esophageal and gastric cancer. Conclusion: Low intake of folate was associated with increased risk of esophageal squamous cell carcinoma.
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