Journal
BRITISH JOURNAL OF CANCER
Volume 108, Issue 1, Pages 1-8Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2012.569
Keywords
pancreatic ductal adenocarcinoma; hyaluronic acid; interstitial fluid pressure; stromal resistance; desmoplasia; hyaluronidase
Categories
Funding
- NCI [CA129537, CA161112, CA152249, CA159240]
- Giles W. and Elise G. Mead Foundation
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Pancreatic ductal adenocarcinomas (PDAs) are notoriously aggressive and resistant to treatment. They distinguish themselves further by their robust fibroinflammatory, or desmoplastic, stromal reaction and degree of hypovascularity. Recent findings have revealed multiple mechanisms of stromal complicity in disease pathogenesis and resistance. In this review, we focus on altered physicomechanics as one mechanism of what we term as 'stromal resistance' in PDA. Extremely high interstitial fluid pressures and a dense extracellular matrix combine to limit the delivery and distribution of therapeutic agents. We discuss the genesis and consequences of altered fluid dynamics in PDA and strategies to restore them.
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