Journal
BRITISH JOURNAL OF CANCER
Volume 108, Issue 4, Pages 771-774Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2013.41
Keywords
advanced gastric cancer; advanced oesophageal cancer; cetuximab; docetaxel
Categories
Funding
- Merck Serono
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Background: Cetuximab can reverse chemotherapy resistance in colorectal cancer. This study evaluated the efficacy and safety of the combination of docetaxel and cetuximab as a second-line treatment in docetaxel-refractory oesophagogastric cancer. Methods: Patients received docetaxel 30 mg m(-2) on days 1 and 8, every 3 weeks and cetuximab 400 mg m(-2) on day 1, then 250 mg m(-2) weekly. Biomarker mutation analysis was performed. Results: A total of 38 patients were enrolled. Response rates were PR 6% (95% Cl 2-19%), s.d. 43% (95% Cl 28-59%). Main grade 3/4 toxicities were febrile neutropenia, anorexia, nausea, diarrhoea, stomatitis, and acneiform rash. Median progression-free and overall survival were 2.1 and 5.4 months, respectively. A landmark analysis showed a trend to improved survival times with increased grade of acneiform rash. No KRAS, BRAF or PIK3CA mutations were observed. Conclusion: Cetuximab and docetaxel achieve modest responses rates, but maintain comparable survival times to other salvage regimens with low rates of toxicity.
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