Journal
BRITISH JOURNAL OF CANCER
Volume 109, Issue 2, Pages 307-311Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2013.339
Keywords
colorectal cancer; PRRX1; epithelial-to-mesenchymal transition; EMT; metastasis
Categories
Funding
- CREST
- Japan Science and Technology Agency (JST)
- Funding Program for Next Generation World-Leading Researchers [LS094]
Ask authors/readers for more resources
Background: Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated. Methods: We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets. Results: PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC. Conclusion: PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available