Journal
BRITISH JOURNAL OF CANCER
Volume 107, Issue 8, Pages 1207-1212Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2012.398
Keywords
metabolism; angiogenesis; cancer therapy; endothelial cell; Notch; VEGF
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Funding
- Cancer Research UK
- Breast Cancer Research Foundation
- NHS Biomedical Research Centre, Oxford, UK
- Cancer Research UK [11359] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10163] Funding Source: researchfish
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Tumour tissue is characterised by fluctuating oxygen concentrations, decreased nutrient supply, and acidic pH. The primarily glycolytic metabolism of tumour cells contributes to this, with increased glucose consumption and increased lactate secretion. Endothelial cells are particularly challenged when recruited towards the tumour metabolic environment. They are required to proliferate and form functional networks in order to establish continuous blood flow. Considering that deregulated metabolism is an emerging hallmark of cancer and target of tumour therapy, it is of importance to incorporate the current knowledge about how the tumour metabolic environment, as a therapy target, can affect endothelial cell metabolism and the angiogenic response. Recent studies have shown differences in metabolic pathways in endothelial cells compared with other normal or tumour tissues. Therefore, we have reviewed relevant literature on endothelial metabolism and the response to angiogenic activation in conditions of metabolic stress. British Journal of Cancer (2012) 107, 1207-1212. doi:10.1038/bjc.2012.398 www.bjcancer.com (C) 2012 Cancer Research UK
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