Journal
FUTURE CARDIOLOGY
Volume 6, Issue 3, Pages 373-393Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FCA.10.10
Keywords
cardiac development; congenital heart disease; genetic mutations; homeobox; transcription factor; wild-type mutation
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Congenital heart disease is one of the most important chapters in medicine because its incidence is increasing and nowadays it is close to 1.2%. Most congenital heart disorders are the result of defects during embryogenesis, which implies that they are due to alterations in genes involved in cardiac development. This review summarizes current knowledge regarding the molecular mechanisms involved in cardiac development in order to clarify the genetic basis of congenital heart disease.
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