Journal
BRITISH JOURNAL OF CANCER
Volume 107, Issue 2, Pages 221-223Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2012.273
Keywords
metachronous cancer; contralateral breast cancer; patterns of metastasis
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Funding
- Cancer Research UK
- Royal Thai Government
- National Institute for Research (NIHR) Biomedical Research Centre based at Guy's
- St Thomas' NHS Foundation Trust
- King's College London
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BACKGROUND: The understanding of metastatic patterns after metachronous contralateral breast cancer (CBC) may help determine the biological nature of CBC. METHODS: A cohort of 8478 women with breast cancer treated at Guy's and St Thomas' NHS Foundation Trust between 1975 and 2006 were studied. Organ-specific 5-year cumulative incidence and incidence rate ratios were assessed for women diagnosed with unilateral breast cancer (UBC), CBC within 5 years and CBC more than 5 years of the initial diagnosis. RESULTS: Women diagnosed with CBC within 5 years had a higher incidence of metastases in all organs compared with UBC. Women with a short interval time to CBC developed metastasis more rapidly and were more likely to develop visceral and distant cutaneous metastases compared with bone metastasis. CONCLUSION: These findings explain poor prognosis of women with early occurring CBC and suggest that some of these CBCs are indicators of aggressive and/or systemic disease. British Journal of Cancer (2012) 107, 221-223. doi:10.1038/bjc.2012.273 www.bjcancer.com Published online 26 June 2012 (c) 2012 Cancer Research UK
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