Journal
BRITISH JOURNAL OF CANCER
Volume 107, Issue 9, Pages 1595-1601Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2012.405
Keywords
MIF; DJ-1; geographical differences; gastric cancer
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Funding
- University of Birmingham
- Chugai Pharmaceutical Co. Ltd.
- Birmingham Science City
- National Institute for Health Research [ACF-2009-09-011] Funding Source: researchfish
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BACKGROUND: There is a need for sensitive and specific blood-borne markers for the detection of gastric cancer. Raised serum macrophage inhibitory factor (MIF) levels have been proposed as a marker for gastric cancer diagnosis but, to date, studies have only encompassed patients from high-incidence areas. METHODS: We have compared the serum concentration of MIF in a large cohort of UK and Japanese gastric cancer patients, together with appropriate control subjects (age and gender matched). Carcinoembryonic antigen and H. pylori IgG were also measured, as was DJ-1, a novel candidate protein biomarker identified by analysis of gastric cancer cell line secretomes. RESULTS: Marked elevations of the serum concentration of MIF and DJ-1 were seen in Japanese patients with gastric cancer compared with Japanese controls, a trend not seen in the UK cohort. These results could not be accounted for by differences in age, disease stage or H. pylori status. CONCLUSION: In regions of high, but not low incidence of gastric cancer, both MIF and DJ-1 have elevated serum concentrations in gastric cancer patients, compared with controls. This suggests that differing mechanisms of disease pathogenesis may be at play in high-and low-incidence regions. British Journal of Cancer (2012) 107, 1595-1601. doi:10.1038/bjc.2012.405 www.bjcancer.com Published online 11 September 2012 (C) 2012 Cancer Research UK
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