Journal
BRITISH JOURNAL OF CANCER
Volume 104, Issue 5, Pages 882-885Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6606045
Keywords
physical activity; colon adenoma; colon polyp
Categories
Funding
- American Cancer Society
- [CA091842]
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BACKGROUND: Little evidence is available on the relation of physical activity with colon adenomas, a colon cancer precursor. METHODS: We conducted a systematic literature review and meta-analysis of published studies (in English) through April 2010, examining physical activity or exercise and risk or prevalence of colon adenoma or polyp. Random effects models were used to estimate relative risks (RRs) and corresponding confidence intervals (CIs). A total of 20 studies were identified that examined the association and provided RRs and corresponding 95% CIs. RESULTS: A significant inverse association between physical activity and colon adenomas was found with an overall RR of 0.84 (CI: 0.77-0.92). The association was similar in men (RR 0.81, CI: 0.67-0.98) and women (RR 0.87, CI: 0.74-1.02). The association appeared slightly stronger in large/advanced polyps (RR 0.70, CI: 0.56-0.88). CONCLUSION: This study confirms previous reports of a significant inverse association of physical activity and colon adenoma, and suggests that physical activity can have an important role in colon cancer prevention. British Journal of Cancer (2011) 104, 882-885. doi: 10.1038/sj. bjc. 6606045 www. bjcancer. com Published online 8 February 2011 & 2011 Cancer Research UK
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