Journal
BRITISH JOURNAL OF CANCER
Volume 105, Issue 4, Pages 586-591Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2011.266
Keywords
ataxia telangiectasia; ATM; ATM kinase; lymphoma; breast cancer
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Funding
- Cancer Research UK [11022, 10118] Funding Source: researchfish
- Cancer Research UK [11022, C1016/A7395, 10118] Funding Source: Medline
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BACKGROUND: Immunodeficiency in ataxia telangiectasia (A-T) is less severe in patients expressing some mutant or normal ATM kinase activity. We, therefore, determined whether expression of residual ATM kinase activity also protected against tumour development in A-T. METHODS: From a total of 296 consecutive genetically confirmed A-T patients from the British Isles and the Netherlands, we identified 66 patients who developed a malignant tumour; 47 lymphoid tumours and 19 non-lymphoid tumours were diagnosed. We determined their ATM mutations, and whether cells from these patients expressed any ATM with residual ATM kinase activity. RESULTS: In childhood, total absence of ATM kinase activity was associated, almost exclusively, with development of lymphoid tumours. There was an overwhelming preponderance of tumours in patients <16 years without kinase activity compared with those with some residual activity, consistent with a substantial protective effect of residual ATM kinase activity against tumour development in childhood. In addition, the presence of eight breast cancers in A-T patients, a 30-fold increased risk, establishes breast cancer as part of the A-T phenotype. CONCLUSION: Overall, a spectrum of tumour types is associated with A-T, consistent with involvement of ATM in different mechanisms of tumour formation. Tumour type was influenced by ATM allelic heterogeneity, residual ATM kinase activity and age. British Journal of Cancer (2011) 105, 586-591. doi:10.1038/bjc.2011.266 www.bjcancer.com Published online 26 July 2011 (C) 2011 Cancer Research UK
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