Journal
BRITISH JOURNAL OF CANCER
Volume 105, Issue 6, Pages 864-869Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2011.307
Keywords
SNPs; prostate cancer; association studies
Categories
Funding
- Society of Memorial Sloan-Kettering Cancer Center
- Sharon Levine Corzine Cancer Research Initiative
- Kate and Robert Niehaus Clinical Cancer Genetics Initiative
- Fonds de la Recherche en Sante du Quebec
- National Institutes of Health research
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BACKGROUND: Recently, numerous prostate cancer risk loci have been identified, some of which show association in specific populations. No study has yet investigated whether these single nucleotide polymorphisms (SNPs) are associated with prostate cancer in the Ashkenazi Jewish (AJ) population. METHODS: A total of 29 known prostate cancer risk SNPs were genotyped in 963 prostate cancer cases and 613 controls of AJ ancestry. These data were combined with data from 1241 additional Ashkenazi controls and tested for association with prostate cancer. Correction for multiple testing was performed using the false discovery rate procedure. RESULTS: Ten of twenty-three SNPs that passed quality control procedures were associated with prostate cancer risk at a false discovery rate of 5%. Of these, nine were originally discovered in studies of individuals of European ancestry. Based on power calculations, the number of significant associations observed is not surprising. CONCLUSION: We see no convincing evidence that the genetic architecture of prostate cancer in the AJ population is substantively different from that observed in other populations of European ancestry. British Journal of Cancer (2011) 105, 864-869. doi: 10.1038/bjc.2011.307 www.bjcancer.com Published online 9 August 2011 (C) 2011 Cancer Research UK
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