Journal
BRITISH JOURNAL OF CANCER
Volume 102, Issue 4, Pages 710-718Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6605537
Keywords
stathmin1; gastric cancer; proliferation; migration
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Funding
- Medical Research Institute [2008-7]
- Pusan National University
- Korean government (MOEHRD) [KRF-2006-331-E00057]
- Ministry for Health, Welfare and Family affairs, Republic of Korea [0920050]
- National Research Foundation of Korea [전06A1106] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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BACKGROUND: Stathmin1 is a microtubule-regulating protein that has an important role in the assembly and disassembly of the mitotic spindle. The roles of stathmin1 in carcinogenesis of various cancers, including prostate and breast cancer, have been explored. However, its expression and roles in gastric cancer have not yet been described. METHODS: Stathmin1 expression in paraffin-embedded tissue sections from 226 patients was analysed by immunohistochemistry. Roles of stathmin1 were studied using a specific small interfering RNA (siRNA). RESULTS: The expression of stathmin1 was positively correlated with lymph node metastasis, TNM stages and vascular invasion, and negatively with recurrence-free survival, in the diffuse type of gastric cancer. The median recurrence-free survival in patients with a negative and positive expression of stathmin1 was 17.0 and 7.0 months, respectively (P = 0.009). When the expression of stathmin1 was knocked down using siRNA, the proliferation, migration and invasion of poorly differentiated gastric cancer cells in vitro were significantly inhibited. Moreover, stathmin1 siRNA transfection significantly slowed the growth of xenografts in nude mice. CONCLUSION: These results suggest that stathmin1 can be a good prognostic factor for recurrence-free survival rate and is a therapeutic target in diffuse-type gastric cancer. British Journal of Cancer (2010) 102, 710-718. doi:10.1038/sj.bjc.6605537 www.bjcancer.com Published online 19 January 2010 (C) 2010 Cancer Research UK
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