Journal
BRITISH JOURNAL OF CANCER
Volume 103, Issue 8, Pages 1144-1148Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6605901
Keywords
lung cancer; microRNA; oncogene; tumour suppressor; risk stratification; personalised medicine
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Funding
- NRPGM [NSC98-3112-B-002-041]
- NTU [97R0066-08]
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MicroRNAs ( miRNAs) are small non-protein-coding RNAs that function as endogenous negative gene regulators. Dysfunctions of miRNAs are frequently found in malignancies, including lung cancer. In this review, we summarise the current understanding of miRNAs in lung cancer tumourigenesis, and highlight their potential in overcoming drug resistance, abetting histological sub-classification techniques, and serving as biomarkers for lung cancer risk stratification and outcome prediction. British Journal of Cancer ( 2010) 103, 1144-1148. doi:10.1038/sj.bjc.6605901 www.bjcancer.com Published online 21 September 2010 (C) 2010 Cancer Research UK
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