Journal
BRITISH JOURNAL OF CANCER
Volume 103, Issue 7, Pages 1085-1088Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6605843
Keywords
prevalence; risk factor; esophageal cancer; precursor lesion; China
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Funding
- Natural Science Foundation of China [30430710, 30930102]
- National Ministry of Science and Technology [2006AA2Z467, 2006AA02A403]
- Public Welfare Industry of Health [200902002-8]
- Natural Science Foundation of Beijing [7100001]
- Beijing Project on Science and Technology Commission [Z09050703080902]
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BACKGROUND: The etiology of esophageal squamous cell cancer (ESCC) in high prevalence regions of China remains unclear. METHODS: Endoscopic biopsies were conducted among 7381 inhabitants aged from 25 to 65 of Anyang, China. RESULTS: In this study, 2.57, 0.20 and 0.16% of the participants had mild, moderate and severe squamous dysplasia, respectively; 0.19 and 0.08% showed squamous carcinoma in situ and invasive ESCC. Using deep well (depth >100 meters) as water source (odds ratio = 0.72, 95% confidence interval: 0.54-0.96) was negatively associated with ESCC and its precursors, whereas tobacco and alcohol use were not significantly associated with ESCC. CONCLUSIONS: Water source and other factors in this region need further evaluation by longitudinal studies. British Journal of Cancer (2010) 103, 1085-1088. doi:10.1038/sj.bjc.6605843 www.bjcancer.com Published online 10 August 2010 (C) 2010 Cancer Research UK
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