Journal
BRITISH JOURNAL OF CANCER
Volume 104, Issue 1, Pages 33-36Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6605983
Keywords
Rab proteins; colon cancer; vesicle trafficking; Rab11-FIP; integrin; Smad3
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Funding
- NIH [RO1 DK48370, R21 AR49311]
- VA Merit Review award
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Recent investigations have increasingly focussed attention on the roles of intracellular vesicle trafficking in the regulation of epithelial polarity and transformation. Rab25, an epithelial-specific member of the Rab family of small GTPases, has been associated with several epithelial cancers. Whereas Rab25 overexpression is associated with ovarian cancer aggressive behaviour, Rab25 expression is decreased in human colon cancers independent of stage. Recent studies of mouse models of intestinal and colonic neoplasia have demonstrated that Rab25 deficiency markedly promotes the development of neoplasia. Some of these effects appear related to alterations in b1-integrin trafficking to the cell surface. These findings all suggest that Rab25 is a tumour suppressor for colonic neoplasia. British Journal of Cancer (2011) 104, 33-36. doi:10.1038/sj.bjc.6605983 www.bjcancer.com Published online 9 November 2010 (C) 2011 Cancer Research UK
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