Journal
BRITISH JOURNAL OF CANCER
Volume 100, Issue 10, Pages 1603-1607Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6605058
Keywords
prostate cancer; prostasomes; tumour exosomes; biomarkers
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Funding
- Swedish Cancer Research Foundation [070604, 080560]
- Wenner-Gren Foundation
- Stiftelsen Olle Engkvist Byggmastare
- NCI [CA86355, CA69246]
- Lions Research Foundation
- Umea University, Sweden
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Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2: ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients status. British Journal of Cancer ( 2009) 100, 1603-1607. doi: 10.1038/sj.bjc.6605058 www.bjcancer.com Published online 28 April 2009 (C) 2009 Cancer Research UK
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