Journal
BRITISH JOURNAL OF CANCER
Volume 102, Issue 1, Pages 115-123Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6605465
Keywords
immunotherapy; HLA1; chemotherapy; dendritic cells; immunovisibility
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Funding
- Cancer Vaccine Institute
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BACKGROUND: Some cancer patients are immuno-compromised, and it has been long felt that immune-intervention is not compatible with standard chemotherapies. However, increasing evidence suggests that standard chemotherapy drugs may stimulate beneficial changes in both the immune system and tumour. METHODS: We have assessed the expression of human leucocyte antigen class 1 (HLA1) on tumour cells before and after chemotherapy agents (cyclophosphamide, oxaliplatin or gemcitabine). In addition, we show that chemotherapy-stressed tumour cells may release cytokines that enhance the interactions between dendritic cells (DCs) and T cells into growth media. RESULTS: Here we report that some chemotherapy agents can increase HLA1 expression in tumour cells, even when expression is low. Increases were associated with killing by cytotoxic T cells, which were negated by HLA1-blockade. Furthermore, T-cell function, as indicated by increased proliferation, was enhanced as supernatants derived from tumours treated with chemotherapy augmented DC-maturation and function. CONCLUSIONS: There is evidence that a facet of immune surveillance can be restored by appropriate chemotherapy agents. Also, tumours exposed to some chemotherapy may secrete cytokines that can mature DCs, which ultimately enhances T-cell responses. British Journal of Cancer (2010) 102, 115-123. doi:10.1038/sj.bjc.6605465 www.bjcancer.com Published online 8 December 2009 (C) 2010 Cancer Research UK
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