Journal
BRITISH JOURNAL OF CANCER
Volume 100, Issue 9, Pages 1434-1437Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6605028
Keywords
complex I deficiency; oncocytic thyroid tumour; respiratory chain
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Funding
- Salzburger Krebshilfe
- Vereinigung zur Forderung der padiatrischen Forschung und Fortbildung Salzburg
- Children's Cancer Foundation Salzburg
- OeNB Jubilaumsfonds [12568]
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Oncocytic tumours are characterised by hyperproliferation of mitochondria. We immunohistochemically analysed all enzymes of the oxidative phosphorylation system in 19 oncocytic thyroid tumours. A specific lack of complex I was detected, which was expressed at <5% of the level determined in surrounding non-cancerous tissue.
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