Journal
BRITISH JOURNAL OF CANCER
Volume 101, Issue 10, Pages 1651-1657Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6605350
Keywords
BRCA1; breast cancer; mouse models; tumour suppressor
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Funding
- Dutch Cancer Society [NKI2007-3772, NKI2008-41167]
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A substantial part of all hereditary breast cancer cases is caused by BRCA1 germline mutations. In this review, we will discuss the insights into BRCA1 functions that we obtained from mouse models with conventional and conditional mutations in Brca1. The most advanced models closely resemble human BRCA1-related breast cancer and may therefore be useful for addressing clinically relevant questions. British Journal of Cancer (2009) 101, 1651-1657. doi: 10.1038/sj.bjc.6605350 www.bjcancer.com Published online 29 September 2009 (C) 2009 Cancer Research UK
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