Journal
BRITISH JOURNAL OF CANCER
Volume 98, Issue 4, Pages 677-683Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6604209
Keywords
telomeres; targeted therapeutics; ageing
Categories
Funding
- Cancer Research UK Funding Source: Medline
- NCI NIH HHS [P50 CA070907, P50 CA75907] Funding Source: Medline
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One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally correlates with the reactivation of telomerase. Although there is still much we do not understand about the regulation of telomerase, it remains a very attractive and novel target for cancer therapeutics. Several clinical trials have been initiated, and in this review we highlight some of the most promising approaches and conclude by speculating on the role of telomerase in cancer stem cells.
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