Journal
BRITISH JOURNAL OF CANCER
Volume 100, Issue 2, Pages 228-232Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6604801
Keywords
spliceosome; alternative splicing; planiedolide; E 7107; spliceostatin A
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The spliceosome is a ribonucleoprotein complex involved in RNA splicing, that is, the removal of non-coding introns from precursor messenger RNA. (Alternative) Splicing events may play an essential role in tumourigenesis. The recent discovery that the spliceosome is a target for novel compounds with anticancer activity opens up new therapeutic avenues.
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