Journal
BRITISH JOURNAL OF CANCER
Volume 98, Issue 2, Pages 245-249Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6604087
Keywords
prostate; gene expression; senescence; paracrine; carcinogenesis
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Funding
- NCI NIH HHS [P20 CA103728, P50 CA103728] Funding Source: Medline
- NIDDK NIH HHS [DK69690, R01 DK069690] Funding Source: Medline
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Experimental evidence suggests that ageing-associated alterations in the tissue microenvironment act to promote prostate carcinogenesis. In this review, we survey the cellular state of senescence, review its causes, and describe associations with ageing and cancer. We further discuss senescent stromal gene expression changes, which may mediate these effects, and that may serve as therapeutic targets.
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