Journal
BRITISH JOURNAL OF ANAESTHESIA
Volume 109, Issue 2, Pages 216-218Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bja/aes137
Keywords
allergy; hypersensitivity; sugammadex
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Funding
- Grants-in-Aid for Scientific Research [24659700] Funding Source: KAKEN
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Neuromuscular blocking agents have been implicated in 6070 of anaphylactic events associated with anaesthesia. We report two cases of probable hypersensitivity reaction to sugammadex and an additional suspected but less supported case of possible immune-mediated reaction or other adverse reaction. The patients were given a bolus of sugammadex 100 mg immediately before extubation. In all three patients, a possible allergic reaction was suspected within 4 min of sugammadex administration, but with different degrees of severity. Skin testing was positive in two of these patients. Hypersensitivity to sugammadex unaccompanied by cardiovascular or respiratory symptoms might be missed during the course of anaesthesia. Careful monitoring for possible allergic responses is required in patients who have received sugammadex.
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