Journal
BRITISH JOURNAL OF ANAESTHESIA
Volume 102, Issue 1, Pages 47-54Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bja/aen343
Keywords
heart, cardiac output; liver, transplantation; measurement techniques, thermodilution; monitoring, intensive care; monitoring, intraoperative
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Background: The pulmonary artery catheter is invasive and may cause serious complications. A safe method of cardiac output (CO) measurement is needed. We have assessed the accuracy and reliability of a recently marketed self-calibrating arterial pulse contour CO monitoring system (FloTrac/Vigileo (TM)) in end-stage liver failure patients undergoing liver transplant. The pattern of alterations known as cirrhotic cardiomyopathy, and the transplant procedure itself, provided an evaluation under varying clinical conditions. Methods: The cardiac index was measured simultaneously by thermodilution (CITD: mean of four readings) using a pulmonary artery catheter and pulse contour analysis (CIV: mean value computed by the FloTrac/VigileoTM over the same time period). Readings were made at 10 time-points during liver transplant surgery (T1-T5) and on the intensive care unit (T6-T10). CIV was computed using the latest Vigileo software version 01.10. Results: A total of 290 paired readings from 29 patients were collected. Mean (SD) CITD was 5.2 (1.3) and CIV was 3.9 (0.9) litre min(-1) m(-2), with a corrected for repeated measures bias between readings of 1.3 (0.2) litre min(-1) m(-2) and 95% limits of agreement of 1.5 (0.2) to 4.1 (0.3) litre min(-1) m(-2). The percentage error (2SD(Bias)/meanCI(TD)) was 54%, which exceeded a 30% limit of acceptance. Low peripheral resistance and increasing bias were related (r=0.69; P<0.001). The Vigileo system failed to reliably trend CI data, with a concordance compared with thermodilution below an acceptable level (at best 68% of sequential readings). Conclusions: In cirrhotic patients with hyperdynamic circulation, the Vigileo system showed a degree of error and unreliability higher than that considered acceptable for clinical purposes.
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