Journal
ANALYTICAL CHEMISTRY
Volume 87, Issue 22, Pages 11195-11202Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.5b02567
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Funding
- ARC Centre of Excellence in Convergent Bio-Nano Science and Technology [CE140100036]
- ARC [LP110020044]
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Nanostructure imaging mass spectrometry (NIMS) using porous silicon (pSi) is a key technique for molecular imaging of exogenous and endogenous low molecular weight compounds from fingerprints. However, high-mass-accuracy NIMS can be difficult to achieve as time-of-flight (ToF) mass analyzers, which dominate the field, cannot sufficiently compensate for shifts in measured m/z values. Here, we show internal recalibration using a thin layer of silver (Ag) sputter-coated onto fimctionalized pSi substrates. NIMS peaks for several previously reported fingerprint components were selected and mass accuracy was compared to theoretical values. Mass accuracy was improved by more than an order of magnitude in several cases. This straightforward method should form part of the standard guidelines for NIMS studies for spatial characterization of small molecules.
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