Journal
ACS Chemical Biology
Volume 10, Issue 4, Pages 952-956Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cb500815b
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Funding
- National Institutes of Health (NIH) [R01 GM63271, R01 CA110940]
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The cis vs trans conformation, or shape, of phosphoserine-proline (pSer-Pro), a prevalent motif in cell cycle proteins, may play a significant role in regulating mitosis. We demonstrate that Cdk1-cyclin B, the central mitotic kinase, is specific for the trans conformation, not cis, of synthetic, locked Ser-Pro 11-residue peptide substrates, using LC-MSMS detection and sequencing of phosphorylated products. This substrate stereospecificity may contribute an additional level of mitotic regulation.
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