Journal
GUT MICROBES
Volume 1, Issue 6, Pages 379-382Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/gmic.1.6.13608
Keywords
intestinal parasite; genotype; comparative genomics; protozoa; diarrhea
Categories
Funding
- FORMAS
- SIDA
- VR-M
Ask authors/readers for more resources
We have recently sequenced the genome of the human Giardia intestinalis assemblage B isolate GS.(1) Comparisons to the earlier sequenced genome of the human assemblage A isolate WB showed that the average amino acid identity in 4,300 orthologous proteins was only 78%. Here we discuss these results in the light of new genome sequencing data from the hoofed-animal assemblage E (isolate P15, isolated from a pig) and further characterization of assemblage A and B isolates from humans. There is a highly conserved set of core genes (4,557 genes, 91% of genome) common to all isolates. The largest genomic differences are found in variable, Giardia-specific gene families and a large number of chromosomal rearrangements were detected, even between different chromosomes. Surprisingly, the assemblage E and A isolates are more similar at the amino-acid level than the two human isolates are to each other. This strengthens our earlier data suggesting that humans are infected by two different species of Giardia.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available