Journal
ANALYTICAL CHEMISTRY
Volume 87, Issue 20, Pages 10547-10555Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.5b02811
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Funding
- Spanish Ministry of Science and Innovation [CTQ2011-22410, CTQ2014-54987-P]
- Junta de Comunidades de Castilla-La Mancha [PEII-2014-002-A]
- Albacete Science and Technology Park for the Instituto de Recursos Humanos para la Ciencia y la Tecnologia (INCRECYT)
- Ministry of Science and Innovation
- Ministry of Education, Culture and Sport [SAB2011-0072]
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Conventional methods to determine the kinetic parameters for a certain reaction require multiple, separate isothermal experiments, resulting in time- and material-consuming processes. Here, an approach to determine the kinetic information within a single nonisothermal on-flow experiment is presented, consuming less than 10 mu mol of reagents and having a total measuring time of typically 10 min. This approach makes use of a microfluidic NMR chip hyphenated to a continuous-flow microreactor and is based on the capabilities of the NMR chip to analyze subnanomole quantities of material in the 25 nL detection volume. Importantly, useful data are acquired from the microreactor platform in specific isothermal and nonisothermal frames. A model fitting the experimental data enables rapid determination of kinetic parameters, as demonstrated for a library of isoxazole and pyrazole derivatives.
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