Journal
PSYCHOSIS-PSYCHOLOGICAL SOCIAL AND INTEGRATIVE APPROACHES
Volume 2, Issue 1, Pages 1-11Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/17522430903197384
Keywords
trauma; cognition; psychosis-proneness; twins; genetic risk
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Aims: To investigate the interaction between childhood adversity and genetic risk in the formation of psychotic symptoms, using cognitive speed as indicator of genetic risk. Methods: In a cross-twin, cross-trait analysis of monozygotic twins in the general population, the association between childhood adversity and psychotic symptoms was examined, using a cognitive intermediary phenotype as genetic risk marker. Results: Psychotic symptoms in the proband twin were associated with childhood adversity and, independently, with a measure of cognitive speed in the co-twin. The association between childhood adversity and psychotic symptoms was much stronger (interaction: chi(2)=8.48, p=0.004) if cognitive speed was worse. Conclusion: Higher level of genetic risk associated with psychosis may moderate the impact of childhood adversity on the risk of adult psychotic symptom formation.
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