Journal
BRIEFINGS IN FUNCTIONAL GENOMICS
Volume 13, Issue 6, Pages 471-481Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bfgp/elu032
Keywords
AA9; GH61; cellobiose dehydrogenase; oxidative cellulose degradation
Funding
- Genome Canada
- Genome Quebec
- Bioconversion Network of the Natural Sciences and Engineering Research Council of Canada
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Our understanding of fungal cellulose degradation has shifted dramatically in the past few years with the characterization of a new class of secreted enzymes, the lytic polysaccharide monooxygenases (LPMO). After a period of intense research covering structural, biochemical, theoretical and evolutionary aspects, we have a picture of them as wedge-like copper-dependent metalloenzymes that on reduction generate a radical copper-oxyl species, which cleaves mainly crystalline cellulose. The main biological function lies in the synergism of fungal LPMOs with canonical hydrolytic cellulases in achieving efficient cellulose degradation. Their important role in cellulose degradation is highlighted by the wide distribution and often numerous occurrences in the genomes of almost all plant cell-wall degrading fungi. In this review, we provide an overview of the latest achievements in LPMO research and consider the open questions and challenges that undoubtedly will continue to stimulate interest in this new and exciting group of enzymes.
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