Journal
BRIEFINGS IN FUNCTIONAL GENOMICS
Volume 12, Issue 1, Pages 58-65Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bfgp/els056
Keywords
RNA-binding protein; translation; UTR; RNP; CLIP; ribosome profiling
Funding
- Spanish Ministry of Economy and Competitivness [BFU2009-08243, CSD2009-00080]
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The regulation of mRNA translation is a major checkpoint in the flux of information from the transcriptome to the proteome. Critical for translational control are the trans-acting factors, RNA-binding proteins (RBPs) and small RNAs that bind to the mRNA and modify its translatability. This review summarizes the mechanisms by which RBPs regulate mRNA translation, with special focus on those binding to the 3'-untranslated region. It also discusses how recent high-throughput technologies are revealing exquisite layers of complexity and are helping to untangle translational regulation at a genome-wide scale.
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