Journal
BRIEFINGS IN FUNCTIONAL GENOMICS
Volume 9, Issue 5-6, Pages 391-404Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bfgp/elq028
Keywords
RNA-binding proteins; RNA-binding domains; RBP-RNA interaction; RBP regulatory networks; RBP target identification
Funding
- EMBO
- Swiss National Foundation [CRSII3_127454/1]
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Eukaryotic cells express a large variety of ribonucleic acid-(RNA)-binding proteins (RBPs) with diverse affinity and specificity towards target RNAs that play a crucial role in almost every aspect of RNA metabolism. In addition, specific domains in RBPs impart catalytic activity or mediate protein-protein interactions, making RBPs versatile regulators of gene expression. In this review, we elaborate on recent experimental and computational approaches that have increased our understanding of RNA-protein interactions and their role in cellular function. We review aspects of gene expression that are modulated post-transcriptionally by RBPs, namely the stability of polymerase II-derived mRNA transcripts and their rate of translation into proteins. We further highlight the extensive regulatory networks of RBPs that implement a combinatorial control of gene expression. Taking cues from the recent development in the field, we argue that understanding spatio-temporal RNA-protein association on a transcriptome level will provide invaluable and unexpected insights into the regulatory codes that define growth, differentiation and disease.
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