Journal
BRIEFINGS IN BIOINFORMATICS
Volume 15, Issue 1, Pages 1-19Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bib/bbs075
Keywords
miRNA; functional annotation; functional miRNA-mRNA regulatory modules
Funding
- Schizophrenia Research Institute
- National Health and Medical Research Council [631057]
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- Hunter Medical Research Institute
- Neurobehavioural Genetics Unit
- New South Wales Department of Health
- M.C. Ainsworth Research Fellowship in Epigenetics
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microRNAs (miRNAs) are small endogenous non-coding RNAs that function as the universal specificity factors in post-transcriptional gene silencing. Discovering miRNAs, identifying their targets and further inferring miRNA functions have been a critical strategy for understanding normal biological processes of miRNAs and their roles in the development of disease. In this review, we focus on computational methods of inferring miRNA functions, including miRNA functional annotation and inferring miRNA regulatory modules, by integrating heterogeneous data sources. We also briefly introduce the research in miRNA discovery and miRNA-target identification with an emphasis on the challenges to computational biology.
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