Journal
BRIEFINGS IN BIOINFORMATICS
Volume 12, Issue 5, Pages 489-497Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bib/bbq077
Keywords
Base-calling; next generation sequencing; deep sequencing; illumina; solexa; roche; 454; bustard
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Next-generation sequencing platforms are dramatically reducing the cost of DNA sequencing. With these technologies, bases are inferred from light intensity signals, a process commonly referred to as base-calling. Thus, understanding and improving the quality of sequence data generated using these approaches are of high interest. Recently, a number of papers have characterized the biases associated with base-calling and proposed methodological improvements. In this review, we summarize recent development of base-calling approaches for the Illumina and Roche 454 sequencing platforms.
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