Journal
BRIEFINGS IN BIOINFORMATICS
Volume 12, Issue 5, Pages 436-441Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bib/bbr031
Keywords
orthology; expression divergence; alternative splicing; copy number variants; phenotypic divergence
Funding
- Etat de Vaud
- Swiss Institute of Bioinformatics
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Despite the common assumption that orthologs usually share the same function, there have been various reports of divergence between orthologs, even among species as close as mammals. The comparison of mouse and human is of special interest, because mouse is often used as a model organism to understand human biology. We review the literature on evidence for divergence between human and mouse orthologous genes, and discuss it in the context of biomedical research.
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