Journal
BREAST JOURNAL
Volume 18, Issue 5, Pages 406-414Publisher
WILEY
DOI: 10.1111/j.1524-4741.2012.01275.x
Keywords
cognitive impairment; chemotherapy; longitudinal study; young women
Categories
Funding
- Regional Council (Provence-Alpes-Cote d'Azur, France)
- Research Ministry (FNS)
- General Direction of Health (DGS)
- National Institute of Cancer (INCa)
- charity organization Fondation de France
- charity organization Association pour la Recherche sur le Cancer
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Cognitive impairment (CI) is common after cancer treatments, but little is known about the long-term evolution of CI, especially in premenopausal women. Since September 2005, all consecutive women included in the French National Health Insurance Fund registry with a diagnosis of primary breast cancer, aged 1840 years and living in South Eastern France, were asked to participate in a cohort study, including telephone interviews, medical data, and prescription refills of psychotropic drugs and adjuvant endocrine therapy. At each interview, CI is defined as self-report of frequent memory loss and attention deficits. As of February 2010, 222 women with available medical data had taken part in the 10-, 16-, and 28-month telephone interviews, with CI being reported by 37.4%, 36.5%, and 42.3% of participants, respectively. Tranquilizers dispensation was associated with CI self-report at all three interviews; chemotherapy was reported only at the 28-month interview. At 28 months, besides chemotherapy and tranquilizers dispensation, having a low educational level and not being a native French woman were also independently associated with CI. Reports of CI were common in young women and primarily related to psycho-social vulnerabilities and cancer treatment. As they affect quality of life, long-term CI complaints deserve greater consideration.
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