Journal
BREAST CANCER RESEARCH AND TREATMENT
Volume 144, Issue 1, Pages 11-19Publisher
SPRINGER
DOI: 10.1007/s10549-014-2847-4
Keywords
Estrogen receptor; Metastasis; Tumor evolution; Mutation; Resistance
Categories
Funding
- NIH/NCI [R01-CA72038]
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The idea that somatic ER alpha mutations could play an important role in the evolution of hormone-dependent breast cancers was proposed some years ago (Fuqua J Mammary Gland Biol Neoplasia 6(4):407-417, 2001; Dasgupta et al. Annu Rev Med 65:279-292, 2013), but has remained controversial until recently. A significant amount of new data has confirmed these initial observations and shown their significance, along with much additional work relevant to the treatment of breast cancer. Thus, it is the purpose of this review to summarize the research to date on the existence and clinical consequences of ER alpha mutations in primary and metastatic breast cancer.
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