Journal
BREAST CANCER RESEARCH AND TREATMENT
Volume 142, Issue 3, Pages 529-536Publisher
SPRINGER
DOI: 10.1007/s10549-013-2776-7
Keywords
HOTAIR; Breast cancer; Prognosis; Gene expression; Long non-coding RNA; Metastasis
Categories
Funding
- Danish Council for Independent Research (FSS)
- Danish Ministry of Interior
- University of Southern Denmark
- Danish Council for Strategic Research (DBCG-TIBCAT) Dansk Kraeftforsknings Fond
- Breast Friends
- Fonden til Laegevidenskabens Fremme, Kobenhavns Universitets Fond for Kraeftforskning
- Arkitekt H. Hjortenberg & hustrus D. Hjortenbergs Fond
- Carl J. Beckers Fond
- Grosserer A.V. Lykfeldts Legat
- Tomrermester Jorgen Holm & hustru Elisa F. Hansens Midelegat
- Meta & Hakon Baggers Fond
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Expression of HOX transcript antisense intergenic RNA (HOTAIR)-a long non-coding RNA-has been examined in a variety of human cancers, and overexpression of HOTAIR is correlated with poor survival among breast, colon, and liver cancer patients. In this retrospective study, we examine HOTAIR expression in 164 primary breast tumors, from patients who do not receive adjuvant treatment, in a design that is paired with respect to the traditional prognostic markers. We show that HOTAIR expression differs between patients with or without a metastatic endpoint, respectively. Survival analysis shows that high HOTAIR expression in primary tumors is significantly associated with worse prognosis independent of prognostic markers (P = 0.012, hazard ratio (HR) 1.747). This association is even stronger when looking only at estrogen receptor (ER)-positive tumor samples (P = 0.0086, HR 1.985). In ER-negative tumor samples, we are not able to detect a prognostic value of HOTAIR expression, probably due to the limited sample size. These results are successfully validated in an independent dataset with similar associations (P = 0.018, HR 1.825). In conclusion, our findings suggest that HOTAIR expression may serve as an independent biomarker for the prediction of the risk of metastasis in ER-positive breast cancer patients.
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