Journal
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY
Volume 186, Issue 1, Pages 1-16Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00360-015-0920-x
Keywords
AMPK; Metabolic stress; HSL; ATGL; TOR; eEF2
Categories
Funding
- Interuniversity Attraction Poles Program-Belgian Science Policy [P6/28, P7/13]
- Directorate General Higher Education and Scientific Research, French Community of Belgium
- Fund for Medical Scientific Research (FNRS, Belgium) [3.4518.11]
- EXGENESIS Integrated Project from the European Commission [LSHM-CT-2004-005272]
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AMP-activated protein kinase (AMPK) is a highly conserved eukaryotic protein serine/threonine kinase that controls cellular and whole body energy homoeostasis. AMPK is activated during energy stress by a rise in AMP:ATP ratio and maintains energy balance by phosphorylating targets to switch on catabolic ATP-generating pathways, while at the same time switching off anabolic ATP-consuming processes. Metabolic depression is a strategy used by many animals to survive environmental stress and has been extensively studied across phylogeny by comparative biochemists and physiologists, but the role of AMPK has only recently been addressed. This review first deals with the evolution of AMPK in eukaryotes (excluding plants and fungi) and its regulation. Changes in adenine nucleotides and AMPK activation are described in animals during environmental energy stress, before considering the involvement of AMPK in controlling beta-oxidation, fatty acid synthesis, triacylglycerol mobilization and protein synthesis. Lastly, strategies are presented to validate the role of AMPK in mediating metabolic depression by phosphorylating downstream targets.
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